Oral submucous fibrosis osmf is a chronic insidious disease affecting any part of the oral cavity and sometimes the pharynx. Oral submucous fibrosis fibrotic diseases, in a dosedependent manner in persons with osf 21. This study was designed to determine the effect of pentoxifylline trental on the. It is a premalignant condition and has been on a constant rise either due to an increase in the habitual chewing of pan masala or a decrease in the awareness among the public of the danger of chewing pan masala. Complete details of surgery were explained to the patients and informed consent was obtained from each patient. Oral submucous fibrosis causes, symptoms, treatment and. Pdf oral submucous fibrosis osf is often mocked as a condition. Aloe vera in the treatment for oral submucous fibrosis a. The present study was carried out to compare the efficacy of these newer antioxidants in the management of osmf. The aim of the present study was to compare the efficacy of spirulina and lycopene in the management of osmf.
We searched five different databases for studies meeting our eligibility criteria up to june 30, 2017. Drug treatment of oral sub mucous fibrosis international journal. Pdf an approach to management of oral submucous fibrosis. The treatment of patients with oral submucous fibrosis depends on the degree of clinical involvement. In combination therapy 100 patients with osmf were randomly divided into two groups. Research article assessment of utility of tulsi and. Most treatment modalities in osmf have centered on relief of the burning sensation and release of the fibrotic bands to improve mouth opening.
Patients are advised to do mouthopening exercises, for example, by placing ice. Pdf non surgical approaches in treatment of osf researchgate. The difference between the mouth opening before and after the treatment. In our study group jaggery and turmeric application found to be most easy effective and safe modality of treatment for osmf patients. Effectiveness of pentoxifylline in the treatment of oral. Oral submucous fibrosis osmf is a highrisk precancerous condition characterised by slowly progressive chronic fibrotic disease of the oral cavity and oropharynx, in which the oral mucosa loses its elasticity and develops fibrous bands, which ultimately leads to difficulty in opening the mouth. The pathogenesis is poorly understood and the disease is difficult to treat. Oral submucous fibrosis is chronic, insidious disease affecting the oral cavity and sometimes the pharynx and rarely the tongue. Numerous treatment modalities are currently employed for osmf, ranging from medical and surgical interventions, physiotherapy after cessation of the habit, and usually, a combination of these are used in clinical practice. Classification system for oral submucous fibrosis jiaomr and predominantly aimed at improving mouth movements. Research article assessment of utility of tulsi and turmeric. Pdf aloe vera in the management of oral submucous fibrosis. Unusual complication of intralesional corticosteroid in oral submucous fibrosis patient srikanth g 1, komal s 2, jyotsna r 1 and kalyana c. It results in difficulty to open the mouth and can be disabling to the patient.
The awareness of such a condition among oral physicians can help in timely diagnosis and. Mostly surgical treatment is done on bands seen in buccal mucosa which are the main reason for trismus or decreased mouth opening in patients. Comparison of mouth opening with different nonsurgical. Osmf is associated with immunological changes altered levels of serum immunoglobulins and the effect of treatment especially antioxidants and levamisole on serum ig is not known. It results in progressive inability to open the mouth. Patients are advised to do mouthopening exercises, for example, by. A 20yearold patient with oral submucous fibrosis was treated with contact diode laser under local anesthesia and was followed up for six months. Areca nuts have also been shown to have a high copper content, and chewing areca nuts for 530 minutes significantly increases soluble copper levels in oral fluids. Evaluating the efficacy of pentoxifylline in the treatment. Group a patients were treated with systemic juice and topical aloe vera gel for 3 months. Treatment options for oral submucous fibrosis semantic scholar. Pdf current protocols in the management of oral submucous. Jan 30, 2017 oral submucous fibrosis osmf is a potentially malignant disorder caused by chewing of betel quid. Ibm zos management facility zosmf provides system management functions in a taskoriented, web browserbased user interface with integrated user assistance, so that you can more easily manage the daytoday operations and administration of your mainframe zos systems.
Steroids in patients with moderate oral submucous fibrosis, weekly submucosal intralesional injections or topical application of steroids may help prevent further damage. Management of oral submucous fibrosis with injection of. The main and first step in getting osmf successfully treated is asking the patient to stop areca nuts chewing in the form of panghutkajarda etc and make it clear that only after stopping the habit treatment will. The sex distribution of osmf varies geographically. Role of collagen membrane in the treatment of advanced stage. Oral submucous fibrosis and the role of curcumin in its. Most of the treatment modalities for osmf in practice are circumstantial and most of the studies that tested various treatment regimens lacked good design and follow up. Twenty study subjects with osmf were included in the study. Pdf oral submucous fibrosis osmf is a debilitating condition of. The most common oral site for osmf is buccal mucosa and retromolar region, followed by soft palate, faucial pillars, floor of mouth, tongue. There are many treatment options for oral sub mucous fibrous which are mainly decided by the dentist depending on the stage of osmf. According to a recent study, ktp532 laser release process has been successful in increasing the opening range of the mouth in several patients over a twelve month follow up period. Nov 24, 2012 oral submucous fibrosis osf is an extremely discomforting oral condition that is marked by the development of painful lesions inside the mouth that refuse to go away on their own. The primary cause leading to trismus in osmf may be fibrosis and fibrous band.
The primary cause leading to trismus in osmf may be fibrosis and fibrous band formation in the oral mucosa. Seventyfour patients of oral submucous fibrosis were randomly divided into 2 groups. Surgical treatmet is done in osmf cases which are seen with severe restriction of mouth opening and heavy bands are seen in buccal mucosa, labial mucosa of lower lip, soft palate, uvula. Oral submucous fibrosis osmf is a highrisk premalignant condition predominantly seen in the indian subcontinent. Oral submucous fibrosis osmf is a persistent, progressive, precancerous condition of the oral mucosa, which is related with betel quid chewing habit. Successful treatment of oral submucous fibrosis with local injections of chymotrypsin, hyaluronidase, and dexamethasone is reported. Different nonsurgical treatment modalities in oral submucous. Oral submucous fibrosisa case report medcrave online. Oral submucous fibrosis, a clinically benign but potentially. Unusual complication of intralesional corticosteroid in oral. Chymotrypsinchymotrypsin, an endopeptidase, hydrolyses ester and peptide bonds, thus acting as a proteolytic and anti inflammatory agent. The search words osmf, surgical interventions in osmf, flaps and grafts in treatment of osmf were employed for retrieval of data.
Pdf classification system for oral submucous fibrosis. Oral submucous fibrosis, global epidemiology, areca nut, management. Dec 25, 2014 the search words osmf, surgical interventions in osmf, flaps and grafts in treatment of osmf were employed for retrieval of data. The mean of the mouth opening before treatment was observed to be 23. All patients were males and their ages ranged from 21 to. Unusual complication of intralesional corticosteroid in. It has been tried in the treatment of leukoplakia and also in osmf by kumar et al.
An approach to management of oral submucous fibrosis. The suggested aetiological factor is the practice of certain customshabits of the inhabitants of south east asia. Most patients with oral submucous fibrosis present with moderatetosevere disease. The efficacy on mmo and burning sensation increased with time. Many osmf treatment protocols have been proposed to alleviate the. A wide range of treatment modalities have been used, however, none have evolved as a promising treatment option. All such properties of aloe vera suggest the possibility of its use in the management of oral submucous fibrosis. Moderatetosevere oral submucous fibrosis is irreversible. Areca nut, betal quid, habits, oral sub mucous fibrosis, steroid therapy.
Medical and surgical treatment options for oral submucous. Oral submucous fibrosis an overview sciencedirect topics. Several classifications based on clinical and histological features, have been put forth by various researchers, based on different aspects of osmf. Management of oral submucous fibrosis with injection of hyaluronidase and dexamethasone in grade iii oral submucous fibrosis. Management of oral submucous fibrosis by different. Surgical fibrolysis and skin grafts in the management of. Pentoxifylline, a methylxanthine derivative, has vasodilating properties and is believed to increase the vascularity of the mucosal layer. Scribd is the worlds largest social reading and publishing site. By streamlining some traditional tasks and automating others, zosmf can help to simplify some areas of zos system. A total of 28 patients diagnosed with osmf were treated in sri rajiv gandhi college of. Oral submucous fibrosis osmf, a precancerous condition of the oral cavity, has been studied by a number of workers in the field. Osmf is a chronic condition of the oral cavity which results in permanent disability.
These are injected into the fibrotic bands weekly for 68 weeks with regular monitoring of mouth opening. Interferon gammathis plays a role in treatment of patients with osmf because of its immino regulatory effect. The pathogenesis is obscure, and till date, no definitive therapy is available for the management of osmf. Oral submucous fibrosis osmf is a chronic disorder seen only in persons who chew betel areca catechu nuts, pan masala or gutkha and is characterized by tightening of the buccal, and sometimes palatal and lingual mucosae, causing trismus. The malignant transformation rate of osmf has been reported to be around 7. Comparative efficacy of newer antioxidants spirulina and.
Oral submucous fibrosis osmf is a chronic, insidious, disabling disease involving oral mucosa the oropharynx, and rarely the larynx. Although osmf lacks definitive treatment modalities, our meta. Oral submucous fibrosis osmf is a potentially malignant disorder largely seen in the southasian countries where areca nut is found to be the main predisposing factor. Management of oral submucous fibrosis by different surgical. A total of 25 patients consented for surgical treatment. Oral submucous fibrosis is a chronic, complex, premalignant 1% transformation risk condition of the oral cavity, characterized by juxtaepithelial inflammatory reaction and progressive fibrosis of the submucosal tissues the lamina propria and deeper connective tissues. Know all about the disease, including its possible causes, symptoms, diagnosis and treatment options. Oral submucous fibrosis osmf is a potentially malignant disease that results in progressive juxtaepithelial fibrosis of the oral soft tissues. Efficacy of turmeric in reducing burning sensation in oral.
Osmf is considered as a precancerous condition with a high risk of malignant transformation. Osmf is associated with immunological changes altered levels of serum immunoglobulins. Several glucocorticoids are used for the treatment of osmf, short acting hydrocortisone, intermediate acting triamcinolone and long acting betamethasone. As the disease progresses, the jaws become rigid to the point that the person is unable to open the mouth. Different authors have suggested variety of treatment modalities and have claimed success rates. Role of collagen membrane in the treatment of advanced. Surgical fibrolysis and skin grafts in the management of oral. The available epidemiological data showed a clearcut geographical and ethnic predisposition, which suggested that certain customshabits prevalent among the population groups in southeast asia might be possible etiological factors.
An analysis of the treatment modalities, the reason for the selection of a particular modality, the organization of the sample selection and the followup periods including the proclaimed success. Oral submucous fibrosis osmf is an insidious chronic progressive disease of the oral cavity which is considered as a precancerous condition. The major clinical features of osmf observed and recorded were mouth opening and burning sensation. Though there are many therapeutic procedures available for osmf, prevention is likely to be more effective then treatment. An analysis of the treatment modalities, the reason for the selection of a particular modality, the organization of the sample selection and the followup periods including the proclaimed success rates was done. If the disease is detected at a very early stage, cessation of the habit is sufficient. It is a latest treatment option used for curing osf. The us food and drug administration has not yet approved these drugs for the treatment of oral submucous fibrosis. Oral submucous fibrosis is a well known clinical entity since the time of sushruta as vidari. So, aloe vera being a soothing, simple and safe mode of treatment along with proper habit restriction can be considered to be an effectual protocol in the management of osmf. Use of diode lasers in treatment of oral submucous. Dexamethasone, hyaluronidase, oral submucous fibrosis. The early form of the disease can be treated by medicinal means, however, advance stages needs surgical excision of the fibrotic tissue bands. Although, occasionally preceded by or associated with vesical formation, it is always associated with a juxtaepithelial inflammatory reaction followed by fibroelastic changes of lamina propria with epithelial atrophy, leading to stiffness of oral mucosa and.